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An Introduction to Medicinal Chemistry is the leading text for university courses on this subject. Renowned for being a textbook loved equally by both students and lecturers, it presents complete coverage in an accessible and engaging style. The text begins with the essential biochemistry on which an understanding of medicinal chemistry is built, introducing the structure and function of important drug targets. It then explores how drugs interact with the body and the consequences of those reactions. There is a section on general principles and strategies involved in discovering and designing new drugs, and another on useful ‘tools of the trade’. The text ends with a contemporary look at specific topics within medicinal chemistry, for example, antiviral and anticancer agents; cholinergics and anticholinesterases; and antiulcer agents. Learning features throughout An Introduction to Medicinal Chemistry help to unlock this fascinating subject. A glossary helps to familiarise the language of medicinal chemistry. Boxes present in-depth material and explore how concepts are applied in practice. Key points summarise sections within chapters, providing a basis for revision, and questions at the end of chapters and on the accompanying Online Resource Centre allow the reader to test their understanding and develop molecular modelling skills. Online Resource Centre The Online Resource Centre features: For registered adopters of the book: * Answers to end-of-chapter questions * Figures from the book * Power Point slides * Test Bank questions For students: * Multiple Choice Questions * Web articles * Molecular Modelling Exercises * 3D Rotatable structures.
About the Author
Dr. Graham Patrick gained his BSc Honours at Glasgow University, winning the McKay-Smith Prize for Chemistry. He completed his PhD with Professor Kirby and Professor Robins studying the biosynthesis of gliotoxin and related fungal metabolites. Following this, he worked in the pharmaceutical industry as a research chemist and radiochemist on a variety of projects that included topic areas such as opioids, antibacterial agents and antidepressants. His academic career has included positions at Leeds and Strathclyde Universities as well as the Australian National University. He joined the University of Paisley (now the University of the West of Scotland) in 1990, teaching medicinal chemistry and drug design.
Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry with an emphasis on emerging topics in the biological sciences that are expected to provide the basis for entirely new future therapies. * Reviews on hot topics of interest in small molecule drug discovery heavily pursued by industrial research organizations* Provides preclinical information in the context of chemical structures* Knowledgeable section editors who evaluate invited reviews for scientific rigor
About the Author
Dr. Manoj Desai began his career in the pharmaceutical industry at Pfizer Inc, Central Research Division, Groton, CT (1986-1994) before moving to Chiron Corporation (1994-2003) as Director of medicinal chemistry; he was promoted to Vice President, lead discovery and medicinal chemistry (2000). In October 2003, he was appointed Vice President of medicinal chemistry at Gilead Sciences. At Pfizer, he was responsible for the medicinal chemistry efforts that lead to the discovery of oral Substance P antagonist CP-99994 which became the basis for the discovery of the new anti-emetics. At Chiron he formulated macrobead technology for the synthesis and screening of compound libraries for HTS and built the medicinal chemistry department with focus on kinase inhibitors. At Gilead, he was an active proponent to develop a pharmacoenhancer devoid of antiviral activity to improve the pharmacokinetics of integrase inhibitor elvitegravir. These efforts led to the discovery of Cobicistat which is one of components of StribildTM that was approved by FDA in August 2012 for the treatment of HIV infection. He is co-inventor on patents of Cobicistat (US 8,148,374), StribildTM and Ledipasvir (US 8,273,341; Phase III). Furthermore, his group at Gilead has advanced numerous compounds into clinical development for the treatment of antiviral diseases, cancer and cardiovascular diseases. Dr. Desai obtained Ph.D. in organic chemistry from the M.S. University of Baroda in 1981 working with Dr. Sukh Dev and then carried out post-doctoral fellowships at Purdue University working with Professor Herbert C. Brown (19981-1983) and at Harvard University with Professor Elias J. Corey (1983-1986). During his postdoctoral studies, he worked on natural product isolation, development of asymmetric synthetic methods using organoboranes and total synthesis of complex natural products such as retigeranic acid, ?-trans bergamotene and ginkgolide B. He has co-authored >60 publications in peer reviewed journals and is an inventor on >25 issued patents. Furthermore, Dr. Desai is Editor-in-Chief for Annual Reports in Medicinal chemistry (2012-current), and have co-edited Comprehensive Medicinal Chemistry II (volume 7). In 2013, he co-edited book titled “Successful Strategies for the Discovery of Antiviral Drugs .
Nearly half of the world’s adult population is either clinically obese or overweight. Excess weight increases risk for multiple other chronic diseases and represents a major global health issue. Weight gain results from an imbalance between energy intake and expenditure, which can only be corrected if the physiologic and neuroendocrine systems that have the potential to control energy balance are identified. The first edition of this book reviewed knowledge on the intake of micro- and macronutrients, food choice, and opposing views on whether or not there are mechanisms that control food intake. Appetite and Food Intake: Central Control, Second Edition contains all new chapters and serves as a companion to the first by reviewing current knowledge on neuroendocrine mechanisms that influence food intake and glucose metabolism, including environmental influences on their development, with an emphasis on recent progress in understanding forebrain and hindbrain control of ingestive behavior. In addition, there is a discussion on the benefits derived from novel models for exploring ingestive behavior and the progress that has been achieved due to new technologies. Although major progress is being made in understanding the complex interplay between different control systems, the limits of our knowledge are acknowledged in chapters that review the efficacy of current weight control drugs and the relative importance of fat free mass and body fat in driving food intake.
Applications of Transition Metal Catalysis in Drug Discovery and Development: An Industrial Perspective
This book focuses on the drug discovery and development applications of transition metal catalyzed processes, which can efficiently create preclinical and clinical drug candidates as well as marketed drugs. The authors pay particular attention to the challenges of transitioning academically-developed reactions into scalable industrial processes. Additionally, the book lays the groundwork for how continued development of transition metal catalyzed processes can deliver new drug candidates. This work provides a unique perspective on the applications of transition metal catalysis in drug discovery and development — it is a guide, a historical prospective, a practical compendium, and a source of future direction for the field.
About the Author
MATTHEW L. CRAWLEY, PhD , is the Director of the Community Physician Electronic Medical Records Program at Main Line Health. Previously, he has worked as a medicinal chemist at Pfizer and Wyeth Research. Dr. Crawley is an author of more than twenty publications, and his discoveries have resulted in several patents. BARRY M. TROST, PhD , is Tamaki Professor of Humanities and Sciences in the Department of Chemistry at Stanford University. Dr. Trost has been elected a Fellow of the American Academy of Sciences and member of the National Academy of Sciences. He has served as chairman of the NIH Medicinal Chemistry Study Section, held over 120 university lectureships, and presented over 260 plenary lectures at national and international meetings.
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Diagnosing a genetic skin disease can sometimes be a difficult task for a dermatologist. This is especially true for genodermatoses-generally considered rare diseases seldom seen by practicing clinicians. As a result, professionals often have little experience with their diagnosis. The Atlas of Genodermatoses presents a unique collection of such cases gathered patiently over the course of the years by the authors. It provides an unsurpassed overview of the major genodermatoses encountered in practice, even if only on rare occasions. This book discusses almost 200 inherited diseases of the skin, hair, and nails. The entry for each disease includes its epidemiology, laboratory findings, genetics, pathogenesis, cutaneous and extracutaneous findings, differential diagnosis, disease course, complications, and follow-up and therapy, where appropriate. In addition to being a clinical primer, this atlas is also a work of scientific research. The new edition rewrites the classification of some diseases, adds some newly described conditions, and updates established information with the latest molecular genetic studies and references. Specialists in both dermatology and pediatrics should find the atlas an invaluable frontline resource in the clinic.
About the Author
Gianluca Tadini, MD, Pediatric Dermatology Unit and Pediatric Clinic 1, Department of Pathophysiology and Transplantation, Fondazione IRCCS Ca’ Granda – Ospedale Maggiore Policlinico, University of Milan, Italy Michela Brena, MD, Post-Graduate School of Dermatology and Venereology, University of Milan, Italy Carlo Gelmetti, MD, chairman of the Pediatric Dermatology Unit, Department of Pathophysiology and Transplantation, Fondazione IRCCS Ca’ Granda – Ospedale Maggiore Policlinico, University of Milan, Italy Lidia Pezzani, MD, Post-Graduate School of Medical Genetics, University of Milan, Italy
The gold standard of excellence for 25 years, Frank H. Netter, MD’s Atlas of Human Anatomy offers unsurpassed depictions of the human body in clear, brilliant detail – all from a clinician’s perspective. With its emphasis on anatomic relationships and clinically relevant views, Dr. Netter’s work provides a coherent, lasting visual vocabulary for understanding anatomy and how it applies to medicine today.
About the Author
Frank H. Netter was born in New York City in 1906. He studied art at the Art Students League and the National Academy of Design before entering medical school at New York University, where he received his Doctor of Medicine degree in 1931. During his student years, Dr. Netter’s notebook sketches attracted the attention of the medical faculty and other physicians, allowing him to augment his income by illustrating articles and textbooks. He continued illustrating as a sideline after establishing a surgical practice in 1933, but he ultimately opted to give up his practice in favor of a full-time commitment to art. After service in the United States Army during World War II, Dr. Netter began his long collaboration with the CIBA Pharmaceutical Company (now Novartis Pharmaceuticals). This 45-year partnership resulted in the production of the extraordinary collection of medical art so familiar to physicians and other medical professionals worldwide. Icon Learning Systems acquired the Netter Collection in July 2000 and continued to update Dr. Netter’s original paintings and to add newly commissioned paintings by artists trained in the style of Dr. Netter. In 2005, Elsevier Inc. purchased the Netter Collection and all publications from Icon Learning Systems. There are now over 50 publications featuring the art of Dr. Netter available through Elsevier Inc. Dr. Netter’s works are among the finest examples of the use of illustration in the teaching of medical concepts. The 13-book Netter Collection of Medical Illustrations, which includes the greater part of the more than 20,000 paintings created by Dr. Netter, became and remains one of the most famous medical works ever published. The Netter Atlas of Human Anatomy, first published in 1989, presents the anatomic paintings from the Netter Collection. Now translated into 16 languages, it is the anatomy atlas of choice among medical and health professions students the world over. The Netter illustrations are appreciated not only for their aesthetic qualities, but, more importantly, for their intellectual content. As Dr. Netter wrote in 1949 “clarification of a subject is the aim and goal of illustration. No matter how beautifully painted, how delicately and subtly rendered a subject may be, it is of little value as a medical illustration if it does not serve to make clear some medical point.” Dr. Netter’s planning, conception, point of view, and approach are what inform his paintings and what make them so intellectually valuable. Frank H. Netter, MD, physician and artist, died in 1991.
Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and up-to-date, this book offers a valuable guide to these cellular processes whilst inciting researchers to explore their potentially important connections. Volume 5 comprehensively describes the role of autophagy in human diseases, delivering coverage of the antitumor and protumor roles of autophagy; the therapeutic inhibition of autophagy in cancer; and the duality of autophagy’s effects in various cardiovascular, metabolic, and neurodegenerative disorders. In spite of the increasing importance of autophagy in the various pathophysiological conditions mentioned above, this process remains underestimated and overlooked. As a consequence, its role in the initiation, stability, maintenance, and progression of these and other diseases remains poorly understood. This book is an asset to newcomers as a concise overview of the diverse disease implications of autophagy, while serving as an excellent reference for more experienced scientists and clinicians looking to update their knowledge. Volumes in the Series Volume 1: Molecular Mechanisms. Elucidates autophagy’s association with numerous biological processes, including cellular development and differentiation, cancer, immunity, infectious diseases, inflammation, maintenance of homeostasis, response to cellular stress, and degenerative diseases such as Alzheimer’s, Parkinson’s, Huntington’s, amyotrophic lateral sclerosis, and prion diseases. Volume 2: Role in General Diseases. Describes the various aspects of the complex process of autophagy in a myriad of devastating human diseases, expanding from a discussion of essential autophagic functions into the role of autophagy in proteins, pathogens, immunity, and general diseases. Volume 3: Role in Specific Diseases. Explores the role of autophagy in specific diseases and developments, including: Crohn’s Disease, Gaucher Disease, Huntington’s Disease, HCV infection, osteoarthritis, and liver injury, with a full section devoted to in-depth exploration of autophagy in tumor development and cancer, as well as the relationship between autophagy and apoptosis. Volume 4: Mitophagy. Presents detailed information on the role of mitophagy, the selective autophagy of mitochondria, in health and disease, by delivering an in-depth treatment of the molecular mechanisms involved in mitophagy initiation and execution, as well as the role of mitophagy in Parkinson Disease, cardiac aging, and skeletal muscle atrophy. Volume 5: Role in Human Diseases. Comprehensively describes the role of autophagy in human diseases, delivering coverage of the antitumor and protumor roles of autophagy; the therapeutic inhibition of autophagy in cancer; and the duality of autophagy’s effects in various cardiovascular, metabolic, and neurodegenerative disorders. Volume 6: Regulation of Autophagy and Selective Autophagy. Provides coverage of the mechanisms of regulation of autophagy; intracellular pathogen use of the autophagy mechanism; the role of autophagy in host immunity; and selective autophagy. Volume 7: Role of Autophagy in Therapeutic Applications. Provides coverage of the latest developments in autophagosome biogenesis and regulation; the role of autophagy in protein quality control; the role of autophagy in apoptosis; autophagy in the cardiovascular system; and the relationships between autophagy and lifestyle. Volume 8: Autophagy and Human Diseases. Reviews recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities, and introduces new, more effective therapeutic strategies, in the development of targeted drugs and programmed cell death, providing information that will aid on preventing detrimental inflammation. Volume 9: Necrosis and Inflammation in Human Diseases. Emphasizes the role of Autophagy in necrosis and inflammation, explaining in detail the molecular mechanism(s) underlying the formation of autophagosomes, including the progression of Omegasomes to autophagosomes. . Brings together a wide swathe of experts (oncologists, neurosurgeons, physicians, research scientists, and pathologists) in the field of autophagy to discuss recent developments in this rapidly-advancing field . Discusses the role of autophagy in cancer cell proliferation and death, and the potential of manipulation of autophagy in cancer cells as an avenue for treatment . Covers the importance of autophagy of mitochondria to cellular homeostasis; insulin secretion by pancreatic beta cells; cardiac function; atheroschlerosis; and organ tolerance to ischemic stress . Organized for readers into easy-to-access sections: general applications; role in cancer; and role in cardiovascular, metabolic, and neurodegenerative diseases.
About the Author
Dr. Hayat has published extensively in the fields of microscopy, cytology, immunohistochemistry, immunocytochemistry, and antigen retrieval methods. He is Distinguished Professor, Department of Biological Sciences, Kean University, Union, New Jersey, USA.
Anyone who attempts to read genetics or epidemiology research literature needs to understand the essentials of biostatistics. This book, a revised new edition of the successful Essentials of Biostatistics has been written to provide such an understanding to those who have little or no statistical background and who need to keep abreast of new findings in this fast moving field. Unlike many other elementary books on biostatistics, the main focus of this book is to explain basic concepts needed to understand statistical procedures.
- Surveys basic statistical methods used in the genetics and epidemiology literature, including maximum likelihood and least squares.
- Introduces methods, such as permutation testing and bootstrapping, that are becoming more widely used in both genetic and epidemiological research.
- Is illustrated throughout with simple examples to clarify the statistical methodology.
- Explains Bayes’ theorem pictorially.
- Features exercises, with answers to alternate questions, enabling use as a course text.
Written at an elementary mathematical level so that readers with high school mathematics will find the content accessible. Graduate students studying genetic epidemiology, researchers and practitioners from genetics, epidemiology, biology, medical research and statistics will find this an invaluable introduction to statistics.
Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, providing comprehensive explanations of enabling technologies such as high throughput screening, structure based drug design, molecular modeling, pharmaceutical profiling, and translational medicine, all areas that have become critical steps in the successful development of marketable therapeutics. The text introduces the fundamental principles of drug discovery and development, also discussing important drug targets by class, in vitro screening methods, medicinal chemistry strategies in drug design, principles in pharmacokinetics and pharmacodynamics, animal models of disease states, clinical trial basics, and selected business aspects of the drug discovery process. It is designed to enable new scientists to rapidly understand the key fundamentals of drug discovery, including pharmacokinetics, toxicology, and intellectual property.” * Provides a clear explanation of how the pharmaceutical industry works * Explains the complete drug discovery process, from obtaining a lead, to testing the bioactivity, to producing the drug, and protecting the intellectual propertyIdeal for anyone interested in learning about the drug discovery process and those contemplating careers in the industry * Explains the transition process from academia or other industries.
About the Author
As an industrial medicinal chemist, Dr. Blass has experience with major pharmaceutical organizations (Wyeth, Procter & Gamble Pharmaceuticals) and small biotech operations (Fox Chase Chemical Diversity Center), which provided him with a wealth of expertise in the art of drug discovery and development (including a wide range of disease states and biological targets). His position with Temple University’s School of Pharmacy and the Moulder Center for Drug Discovery has provided him with essential experience as an educator and academic scientist. These experiences, as well as his training and expertise as a registered US patent agent, have provided him with the tools and skills necessary to bridge the gap between industrial drug discovery and academic research.
The 11th edition of the pre-eminent textbook on physical examination contains foundational content to guide students’ approaches to history taking, interviewing, and other core assessment skills, as well as fully illustrated, step-by-step techniques that outline correct performance of physical examination. The book features a vibrant full-color art program and an easy-to-follow two-column format with step-by-step examination techniques on the left and abnormalities with differential diagnoses on the right. The comprehensive, evidence-based content is intended for medical students, high-level nursing education and practice markets, as well as related health professions such as physician assistants. New for this edition: content has been fully revised and updated to reflect the most recent health care literature; more than 200 new and revised photographs and drawings have been added to better illustrate key points in the accompanying text; design and layout has been revised to increase discoverability of core material and special assessment tips; and, techniques of interviewing chapter has been reorganized to provide clearer insights into the skills of empathic listening.
The 11th edition of the pre-eminent textbook on physical examination contains foundational content to guide students' approaches to history taking, interviewing, and other core assessment skills, as well as fully illustrated, step-by-step techniques that outline correct performance of physical examination. The book features a vibrant full-color art program and an easy-to-follow two-column format with step-by-step examination techniques on the left and abnormalities with differential diagnoses on the right. The comprehensive, evidence-based content is intended for medical students, high-level nursing education and practice markets, as well as related health professions such as physician assistants. New for this edition: content has been fully revised and updated to reflect the most recent health care literature; more than 200 new and revised photographs and drawings have been added to better illustrate key points in the accompanying text; design and layout has been revised to increase discoverability of core material and special assessment tips; and, techniques of interviewing chapter has been reorganized to provide clearer insights into the skills of empathic listening.
This concise pocket-sized guide presents the classic Bates approach to physical examination and history taking in a quick-reference outline format. It contains all the critical information needed to obtain a clinically meaningful health history and conduct a thorough physical assessment. Fully revised and updated to reflect current health care literature, the Seventh Edition will help health professionals elicit relevant facts from the patient’s history, review examination procedures, highlight common findings, learn special assessment techniques, and sharpen interpretive skills. The book features a vibrant full-color art program and an easy-to-follow two-column format with step-by-step examination techniques on the left and abnormalities with differential diagnoses on the right.
A title within the Nursing and Health Care Practice series, Beginning Reflective Practice provides pre-registration nursing and health care students with all the tools required to fully understand and develop skills for reflective practice, with the goal of becoming a successful reflective practitioner. Clearly written and highly accessible, this new edition includes a wide number of examples and illustrations to assist with learning and understanding, simple introductions to theoretical perspectives along with key developments in nursing including the growing role of e-learning technologies, the relationship between reflective learning and evidence-based practice, and the increasingly recognised linkage between reflection, professional judgement and accountability. Fully up-to-date in line with NMC standards, this is an indispensable text for every trainee reflective practitioner. This textbook is autopackaged with CourseMate. CourseMate brings course concepts to life with interactive learning, study, and exam preparation tools that support the printed textbook and the textbook-specific website. CourseMate includes an integrated eBook and interactive teaching and learning tools including quizzes, flashcards, videos, and more and an EngagementTracker, a first-of-its-kind tool that monitors student engagement in the course.