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“New experimental techniques in immunology have produced large and complex data sets that require quantitative modeling for analysis. This book provides a complete overview of computational immunology, from basic concepts to mathematical modeling at the single molecule, cellular, organism, and population levels. It showcases modern mechanistic models and their use in making predictions, designing experiments, and elucidating underlying biochemical processes. It begins with an introduction to data analysis, approximations, and assumptions used in model building. Core chapters address models and methods for studying immune responses, with fundamental concepts clearly defined”–
This unique analysis of neuropsychological conditions provides readers with a review of both pediatric and adult presentations in one convenient place. Covering the most common disorders encountered in clinical practice, including those specific to the extremes of the age spectrum, this book provides dedicated chapters on: * Preterm and low weight birth * Spina bifida myelomeningocele * Autism spectrum disorder * Intellectual disability * Fetal alcohol spectrum disorders * Attention-deficit/hyperactivity disorder * Learning disability * Traumatic brain injury * Cancer * Epilepsy * Human immunodeficiency virus * Multiple sclerosis * Stroke * Dementia Each chapter provides evidence-based guidelines that can be readily applied to daily practice.
Master the effective evaluation, analysis and management of placental-fetal growth restriction (PFGR), developing strategies to reduce the risk of perinatal mortality and morbidity in patients worldwide. Extensively researched by international experts, this manual provides practitioners with a detailed, hands-on approach to the practical ‘pearls’ for direct patient management. This authoritative volume advises on matters such as the correct evaluation and management of high-risk patients in danger of PFGR through to delivery. Extensive and wide-ranging, this book is an invaluable companion to the developing research interest and clinical applications in PFGR, including developmental outcomes in early childhood. Featuring a critical evaluation of a variety of abnormal conditions, such as fetal hypoxia and extreme prematurity, which are clearly displayed through extensive illustrations. This essential toolkit ensures that practitioners at all levels can effectively limit adverse outcome and reach the correct diagnosis.
This spin-off from Stephen M. Stahl’s new, completely revised, and fully updated sixth edition of the Prescriber’s Guide covers the most important drugs in use today for treating patients suffering from psychotic illness. Now established as the indispensable formulary in psychopharmacology, easy to navigate and easy to use, the Prescriber’s Guide combines evidence-based information with clinically informed guidance to support clinicians in making the most effective prescribing decisions for the good of their patients. Incorporating information on the newest indications, new formulations, new recommendations and new safety data, this edition continues to provide the essential practical support required by anyone prescribing in the field of mental health.
It is estimated that 1.5 million infants undergo surgery and anesthesia in the USA each year. However, there are serious concerns within the pediatric anesthesia community regarding the safety of anaesthesia in infants and children. There is mounting evidence from animal studies that anesthetics in common clinical use are neurotoxic to the developing brain and cause long-term neurobehavioral abnormalities. Essentials of Anesthesia for Infants and Neonates provides a comprehensive guide to the special needs of infants undergoing anesthesia. It focuses on the first year of life, the time when anesthesia mortality and morbidity is highest. Chapters are illustrated in color throughout, and include sections on newborn physiology for anesthetic management, specific procedures, pain management, and topics such as regional anesthesia and sedation. Written by nationally recognized experts, this book will become an invaluable point of reference for any physician interested in pain management in the first year of life.
Research Methods in Radiology provides concise, practical insights on how to design clinical and experimental studies in diagnostic imaging. This unique resource encompasses contributions from leaders in academic radiology as well as top epidemiologists, biostatisticians, and librarians with vast multidisciplinary and radiology research experience. The material reflects years of expertise teaching core biostatistics in radiology principles to residents, fellows, radiologists, and epidemiologists. Given the vast amount of published information on research methodology and statistics in radiology, the authors’ goal was to write a high-yield review and study tool rather than a comprehensive book. Key topics are succinctly addressed in each chapter, including measurements in radiology; decision analysis in radiology; and systemic reviews, evidence-based imaging, and knowledge translation. Online exercises related to each topic enable residents to prepare for radiology board examinations and research radiologists to apply knowledge to clinical studies. Key Highlights Introductory chapters on analysis of diagnostic tests, linear and logistic regression, meta-analysis, statistical inference, and economic evaluation provide easy-to-follow tutorials Each chapter includes learning objectives, basic concepts, supplementary tables, and ancillary online material Case studies with images, graphs, and tables highlight primary “take home” points Sample size calculations are illustrated for a wide range of research questions Code is included for use in R, free open-source software for statistical analysis This book is an indispensable review of research methodology for radiology students and residents. Practicing clinicians will also benefit from this precisely focused reference tool on clinical and experimental research.
Lippincott Illustrated Reviews: Neuroscience presents essential coverage of this core basic science discipline within an integrated framework, bringing neuroanatomy and neurophysiology together and demonstrating how they are applied in a clinical context. It offers all the most popular features of the bestselling Lippincott Illustrated Reviews series, including abundant full-color, annotated illustrations, chapter overviews, an expanded outline format, chapter summaries, and review questions that link basic science to real-life clinical situations. Master state-of-the-art neuroscience information through comprehensive updates reflecting the latest research. Understand the practical applications of basic neuroanatomy and neurophysiology with expanded clinical examples throughout and NEW Clinical Cases at the end of each chapter that guide you to apply your knowledge to clinical scenarios. Visualize neuroscience concepts more clearly with the aid of many new and improved full-color illustrations. Review and assimilate large amounts of complex information via the Lippincott Illustrated Reviews series’ signature outline format. Extend your learning online with access to animations and an interactive question bank.
Clinical high-yield content covers what you need to know for the USMLE, shelf exam, and your Obstetrics & Gynecology rotation! This best-selling Blueprints title is an ideal resource for the obstetrics and gynecology rotation and board preparation. This is the perfect companion for quick study breaks during rotation downtime, with concise chapters that appeal to students who want a review of key concepts, research, and therapies in today’s practice. Blueprints are also utilized by students in physician assistant, nurse practitioner, and osteopathic programs, as well as residents preparing for USMLE Step 3. Features include: Expanded coverage of topics, evidence-based research, therapies, and the latest changes in the management of cervical dysplasia and cervical cancer screening, abnormal uterine bleeding, hypertension in pregnancy, cervical insufficiency, prenatal diagnosis, and preterm labor. Updates on the latest techniques in contraception, sterilization, and hormone replacement, as well as current treatment options for uterine fibroids and ovarian cysts. Updated tables and figures that improve student’s assimilation and retention of information. Case-based clinical vignette questions at the end of each chapter help you review the material and prepare for exams. New and updatedboard-style questions, with full explanations of both correct and incorrect options, increase understanding.
Revised and updated by experts in both nephrology and clinical nutrition, this seventh edition of Handbook of Nutrition and the Kidney provides practical and clinically relevant information for addressing the nutritional needs of patients with acute and chronic kidney disease. Concise yet in-depth, the book is packed with tables and charts in every chapter, and outlines detailed and daily nutritional requirements, including proteins, vitamins, minerals, lipids, other fatty acids, and more. Features: -Useful for physicians, dietitians, nurses, and anyone who works with patients afflicted by chronic kidney disease (CKD), hemodialysis (HD), peritoneal dialysis (PD), and kidney transplants. -Each chapter contains tables and figures that visually demonstrate nutritional principles and enable you to find essential information quickly. -Presents easy-to-follow sample menus with lists of ingredients and dietary recommendations. -Chapters cover the affects of kidney disease on metabolism and hormonal function, nutritional approaches to caring for different patient types, an overview of nutritional biochemistry and digestive physiology in healthy adults, and more. -Includes guidelines and requirements for people with hypertension. Your book purchase includes a complimentary download of the enhanced eBook for iOS, Android, PC & Mac. Take advantage of these practical features that will improve your eBook experience: -The ability to download the eBook on multiple devices at one time-providing a seamless reading experience online or offline. -Powerful search tools and smart navigation cross-links that allow you to search within this book, or across your entire library of VitalSource eBooks. -Multiple viewing options that enable you to scale images and text to any size without losing page clarity as well as responsive design. -The ability to highlight text and add notes with one click.
This text presents an intuitive and robust mathematical image of fundamental particle physics based on a novel approach to quantum field theory, which is guided by four carefully motivated metaphysical postulates. In particular, the book explores a dissipative approach to quantum field theory, which is illustrated for scalar field theory and quantum electrodynamics, and proposes an attractive explanation of the Planck scale in quantum gravity. Offering a radically new perspective on this topic, the book focuses on the conceptual foundations of quantum field theory and ontological questions. It also suggests a new stochastic simulation technique in quantum field theory which is complementary to existing ones. Encouraging rigor in a field containing many mathematical subtleties and pitfalls this text is a helpful companion for students of physics and philosophers interested in quantum field theory, and it allows readers to gain an intuitive rather than a formal understanding.
Master implementation of the techniques of flow cytometry in diagnosing complex haematological diseases and malignancies in patients, worldwide. Featuring World Health Organization recommendations on pre-analytical steps, instrument settings and panel construction, this invaluable manual offers invaluable support for those researching, practising and analyzing the cause of hematological malignancies. Authored by leading experts, this book puts flow-cytometry into everyday context. With a focus on multicolour panels, the manual provides readers an experienced understanding of effective, implementation techniques. Practitioners of all levels are offered a background in a variety of diseases presented alongside the most current methodology. Wide-ranging and comprehensive; detailed images of healthy blood, bone marrow and lymph-nodes are illustrated throughout, allowing for effective diagnosis. Through engaging with differential diagnoses, the manual offers an understanding of similar symptoms and mimicking malignancies, avoiding inaccurate results. Featuring in-depth descriptions of chronic diseases; users can reach accurate diagnosis, first time.
Challenge your knowledge of ultrasound to address sexual health abnormalities and early pregnancy issues, alongside identifying, classifying and managing a wide range of gynaecological conditions, with this essential manual. Authored by experts in reproductive health, this bespoke guide delivers practitioners of all levels with a broad scope of sexual and reproductive disorders, as captured by ultrasound. Presenting operational issues and suggested training, this textbook ensures high-quality care in gynaecology, sexual and reproductive health and pregnancy advisory services. For use in a traditional hospital setting through to more remote locations, this guide provides an invaluable toolkit for trainees, sonographers, nurses and clinicians worldwide. Offering clear clinical ultrasound images and extensive case studies with a focus on pregnancy advisory services, this adaptable textbook provides reliable support for those who are in contact with common, rare and understudied reproductive conditions, wishing to achieve successful diagnosis and optimal imaging first time.