Applications of Transition Metal Catalysis in Drug Discovery and Development: An Industrial Perspective
This book focuses on the drug discovery and development applications of transition metal catalyzed processes, which can efficiently create preclinical and clinical drug candidates as well as marketed drugs. The authors pay particular attention to the challenges of transitioning academically-developed reactions into scalable industrial processes. Additionally, the book lays the groundwork for how continued development of transition metal catalyzed processes can deliver new drug candidates. This work provides a unique perspective on the applications of transition metal catalysis in drug discovery and development — it is a guide, a historical prospective, a practical compendium, and a source of future direction for the field.
About the Author
MATTHEW L. CRAWLEY, PhD , is the Director of the Community Physician Electronic Medical Records Program at Main Line Health. Previously, he has worked as a medicinal chemist at Pfizer and Wyeth Research. Dr. Crawley is an author of more than twenty publications, and his discoveries have resulted in several patents. BARRY M. TROST, PhD , is Tamaki Professor of Humanities and Sciences in the Department of Chemistry at Stanford University. Dr. Trost has been elected a Fellow of the American Academy of Sciences and member of the National Academy of Sciences. He has served as chairman of the NIH Medicinal Chemistry Study Section, held over 120 university lectureships, and presented over 260 plenary lectures at national and international meetings.
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An original account of willful ignorance and how this principle relates to modern probability and statistical methods
Through a series of colorful stories about great thinkers and the problems they chose to solve, the author traces the historical evolution of probability and explains how statistical methods have helped to propel scientific research. However, the past success of statistics has depended on vast, deliberate simplifications amounting to willful ignorance, and this very success now threatens future advances in medicine, the social sciences, and other fields. Limitations of existing methods result in frequent reversals of scientific findings and recommendations, to the consternation of both scientists and the lay public.
Willful Ignorance: The Mismeasure of Uncertainty exposes the fallacy of regarding probability as the full measure of our uncertainty. The book explains how statistical methodology, though enormously productive and influential over the past century, is approaching a crisis. The deep and troubling divide between qualitative and quantitative modes of research, and between research and practice, are reflections of this underlying problem. The author outlines a path toward the re-engineering of data analysis to help close these gaps and accelerate scientific discovery.
Willful Ignorance: The Mismeasure of Uncertainty presents essential information and novel ideas that should be of interest to anyone concerned about the future of scientific research. The book is especially pertinent for professionals in statistics and related fields, including practicing and research clinicians, biomedical and social science researchers, business leaders, and policy-makers.
Provides a systematic review of modern methods and instruments for measuring environmental parameters
• Profiles the most modern methods and instruments for environment control and monitoring
• Gives an assessment of biotic and abiotic factors and their effect on quality of atmosphere and indoor air, soil, water
• Provides a brief description of the main climatic (pressure, wind, temperature, humidity, precipitation, solar radiation), atmospheric, hydrographic, and edaphic factors
• Covers a wide range environmental methods and instrumentation including those used in the fields of meteorology, air pollution, water quality, soil science and more
• Supplied with practical exercises, problems, and tests that will help the reader to learn more deeply contents of the book
From the Back Cover
The first book of its kind, the Life Cycle Assessment Handbook: A Guide for Environmentally Sustainable Products will become an invaluable resource for environmentally progressive manufacturers and suppliers, product and process designers, executives and managers, and government officials who want to learn about this essential component of environmental sustainability.
As the last several decades have seen a dramatic rise in the application of Life Cycle Assessment (LCA) in decision making, the interest in the life cycle concept as an environmental management and sustainability tool continues to grow. The LCA Handbook offers a look at the role that life cycle information, in the hands of companies, governments, and consumers, may have in improving the environmental performance of products and technologies. It concisely and clearly presents the various aspects of LCA in order to help the reader better understand the subject.
The content of the book was designed with a certain flow in mind. After a high-level overview to describe current views and state-of-the-practice of LCA, it presents chapters that address specific LCA methodological issues including creating life cycle inventory, life cycle impact assessment, and capturing eco-systems services. These are followed by example applications of LCA in the agri-food industry; sustainable supply chain management; solid waste management; mining and mineral extraction; forest products; buildings; product innovation; and sustainable chemistry and engineering.
The international success of the sustainability paradigm needs the participation of many stakeholders, including citizens, corporations, academia, and NGOs. The handbook links LCA and responsible decision making and how the life cycle concept is a critical element in environmental sustainability. It covers issues such as building capacity in developing countries and emerging economies so that they are more capable of harnessing the potential in LCA for sustainable development. Governments play a very important role with the leverage they have through procurement, regulation, international treaties, tax incentives, public outreach, and other policy tools. This compilation points to the clear trend for incorporating life cycle information into the design and development processes for products and policies, just as quality and safety concerns are now addressed throughout product design and development.
In this outstanding new handbook:
- A team of international experts leads you step by step through the entire LCA process
- You will learn how to improve the environmental profile of your company’s products and processes with life cycle, cradle-to-grave thinking
- Real-world examples and case studies illustrate how you can use LCA to make sound decisions that lead to more environmentally sustainable choices
- You will hear the experts discuss how holistic thinking can lead to better policymaking, product and process innovation, supplier selection, eco-labeling, and more
Engineers, managers, economists, government policymakers, and scientists throughout industry and economists and engineers working in sustainability, whether in industry or research.
About the Author
MARY ANN CURRAN, PhD, is an internationally recognized expert in the field of life cycle assessment and management. She began working on LCA methodology in 1990 at the U.S. EPA’s National Risk Management Research Laboratory in Cincinnati, Ohio. An author of numerous papers and book chapters on LCA, she has been instrumental in advancing LCA awareness worldwide and has presented her LCA-related research at technical meetings around the world. She serves on the editorial boards of multiple journals on LCA and is a Fellow of the American Institute of Chemical Engineers (AIChE).
This textbook is written by a renowned haematologist with more than 30 years of experience in teaching haematology to medical students and whose pedagogical and writing skills are widely admired within the field. Following closely the current curriculum of Imperial College London, medical students, trainee nurses and biomedical science students from other institutions will find the textbook equally suitable, since it includes the core student haematology curriculum as recommended by the Royal College of Pathologists and the British Society of Haematology expert group. This text will be equally suitable for students outside the UK.
The textbook takes a useful, practical approach, incorporating self-evaluation questions and learning objectives that give students not only the information needed to understand the topic but also clear indications on the core knowledge that students are required to know in order to progress within the field of haematology.