Language : English
Published : 2014-03-09
Pages : 920
Oxford Handbook of Clinical Medicine
Now in its ninth edition, the Oxford Handbook of Clinical Medicine continues to be the definitive pocket-friendly guide to medicine. The culmination over 25 years of experience at the bedside and in the community, this handbook is packed with practical advice, wit, and wisdom. The Oxford Handbook of Clinical Medicine presents clinical information in a clear way that makes it easy to revise, remember, and implement on the ward. It gives reliable advice on what to do, when to do it, and how to do it, with clinical photographs and diagrams that bring theory to life. Uniquely for a medical text, this book weaves history, literature, art, and philosophy into its survey of medicine, casting new light on the specialties and encouraging the reader to see beyond the practical aspects of medicine and adopt a patient-centred approach to care. The Oxford Handbook of Clinical Medicine looks ever, with a more modern design and over 600 colour images and illustrations. The History and Examination chapter has been completely revamped with systematic flowcharts and new illustrations so that it better reflects real bedside practice. The index, cross-references, and references have been overhauled to make them even easier to use. Every chapter has been written with supervision from experts in each field to ensure accuracy, and updated to reflect relevant guidelines from the NHS, NICE, the Resuscitation Council and other key professional bodies. Loved and trusted by generations of doctors, the Oxford Handbook of Clinical Medicine continues to be an indispensable companion for the practice of modern medicine.
About the Author
Murray Longmore is a GP working in Sussex, UK. Ian Wilkinson is Reader in Clinical Pharmacology at the University of Cambridge and an Honorary Consultant Physician in Cambridge, UK. Andrew Baldwin is a GP Registrar working in Sussex, UK. Elizabeth Wallin is a Specialist Registrar in Renal Medicine working in Cambridge, UK.
New and emerging directions in pharmaceutical research to better treat schizophrenia
Although the dopamine hypothesis has been the cornerstone of schizophrenia therapeutics, it is clear that dopamine-based approaches do not treat all aspects of the disease. Moreover, many schizophrenia patients fail to respond to current antipsychotics. Integrating chemistry, biology, and pharmacology, this book explores emerging directions in pharmaceutical research for drug targeting and discovery in order to find more effective treatments for schizophrenia, one of the most serious and widespread psychiatric diseases.
Targets and Emerging Therapies for Schizophrenia presents the basics of schizophrenia, drug targets for the disease, and potential new drugs and therapeutics. It begins with a discussion of prevalence and etiology. Then, it describes therapies such as dopamine agonists and phosphodiesterase (PDE) inhibitors as well as growing research aimed at addressing untreated symptoms. Next, the authors discuss receptor modulators, inhibitors, and targeting strategies for drug discovery. Both the neurobiological and chemical aspects of all major pharmacological targets are examined.
With contributions from an international team of pioneering pharmaceutical researchers, this book compiles the current knowledge in the field, setting the stage for new breakthroughs in the treatment of schizophrenia. Targets and Emerging Therapies for Schizophrenia:
- Provides a comprehensive resource for neuro-drug discovery and the development of molecular targets for schizophrenia treatment
- Draws from chemistry, biology, and pharmacology for more effective drug targeting and discovery
- Explores a wide range of receptors and molecular targets, including dopamine, PDEs, and neuropeptides
With Targets and Emerging Therapies for Schizophrenia as their guide, drug discovery and development scientists have the information they need to advance their own research so that new, more effective treatments for schizophrenia will soon be a reality.
Without medical jargon, Barbara Schildkrout lucidly explains how patients with each medical condition may end up seeking help from a mental health professional.
The conditions explored in this book include:
- Alzheimer’s disease
- Brain tumors
- Carbon monoxide poisoning
- Diseases of the thyroid
- Endocrine disorders
- Hepatic encephalopathy
- Hyperventilation syndrome
- Limbic encephalitis
- Lyme disease
- Thiamine deficiency
- Traumatic brain injury
The book also describes a proven process for working with patients during and after the referral process, and integrating medical findings into ongoing therapeutic work. All mental health professionals need access to this information, and Masquerading Symptoms puts it all in a single, easily navigated reference.BARBARA SCHILDKROUT, MD,is an Assistant Clinical Professor of Psychiatry at Harvard Medical School. She has taught for many years at the Beth Israel Deaconess Medical Center. She has a Subspecialty Board Certification through the United Council for Neurological Subspecialties in behavioral neurology and neuropsychiatry and has maintained a private clinical practice in the Boston area for over 25 years.
About the Author
BARBARA SCHILDKROUT, MD, is an Assistant Clinical Professor of Psychiatry at Harvard Medical School. She has taught for many years at the Beth Israel Deaconess Medical Center. She has a Subspecialty Board Certification through the United Council for Neurological Subspecialties in behavioral neurology and neuropsychiatry and has maintained a private clinical practice in the Boston area for over twenty-five years.
This book is for readers with some background in science, concerning the search for drugs, starting from molecular diversity in nature or molecular wilderness. Drug molecules may be used as such, or as starting points for improved drugs obtained from the interface of chemistry and biology. In some cases, the essential molecular features for drug properties from natural molecules may be identified and modified to more effective ones. In other cases, nature provides the targets, such as essential enzymes from infectious microorganisms, from which synthetic drugs can be designed. The mechanisms of action of drugs can be discerned by studying target-drug interactions. Nature may fight back, as in cases when microorganisms become resistant to drugs, but we can again use the chemistry-biology interface to obtain drugs which overcome the resistance. The battle goes on, hopefully with victory for both humans and balance of nature. This book differs from those available on the subject of natural products and drugs derived therefrom in that it looks at the broad picture on how materials and organisms from nature affect our health and how we have combined our knowledge in chemistry, biology, and biodiversity to promote our wellness from resources in the “molecular wilderness,” with caveats on sustainable utilization of these resources. It is therefore suitable, not only for readers interested in science and medicine, but also for those with interest in policy issues concerning sustainable development, environment, and issues concerning interaction of science and society in general.
About the Author
Prof. Yongyuth Yuthavong is senior research fellow at the National Science and Technology Development Agency (NSTDA) of Thailand. While working at Mahidol University, Thailand, he was given the “Outstanding Scientist of Thailand” Award (1984) for his research on malaria biochemistry. In 2004, he received the Nikkei Asia Prize for Science, Technology and Innovation from Nihon Keizai Shimbun, Inc., Japan, for his work on antimalarial drug targets. He is a former Minister of Science and Technology of Thailand (2006-2008) and was the first president of NSTDA (1992-1998). He is now involved in the development of drugs against drug-resistant malaria as well as policy issues for science and technology, and education in general. He has special interest in introducing science and technology to young people.
This textbook introduces the general points of view of research methodology in the scientific and engineering fields of study. It gives an overview of the technical and professional communication for the purpose of article publication in journals. The text contains a number of practice activities that give beginners the confidence to move on communicative activities. Problem sets are provided in each chapter to examine the reader’s understanding of each concept.