Research Methodologies for Beginners
This textbook introduces the general points of view of research methodology in the scientific and engineering fields of study. It gives an overview of the technical and professional communication for the purpose of article publication in journals. The text contains a number of practice activities that give beginners the confidence to move on communicative activities. Problem sets are provided in each chapter to examine the reader’s understanding of each concept.
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Evidence-Based Validation of Herbal Medicines brings together current thinking and practice in the areas of characterization and validation of natural products. This book reviews all aspects of evaluation and development of medicines from plant sources, including their cultivation, collection, phytochemical and phyto-pharmacological evaluation, and therapeutic potential. Emphasis is placed on describing the full range of evidence-based analytical and bio-analytical techniques used to characterize natural products, including -omic technologies, phyto-chemical analysis, hyphenated techniques, and many more. * Includes state-of-the-art methods for detecting, isolating, and performing structure elucidation by degradation and spectroscopic techniques* Covers biosynthesis, synthesis, and biological activity related to natural products* Consolidates information to save time and money in research* Increases confidence levels in quality and validity of natural products.
About the Author
Dr. Pulok K. Mukherjee, Director, School of Natural Product Studies, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India, has been working on traditional medicine inspired drug discovery leading to development of therapeutic leads from natural resources. His research work highlights screening, evaluation, formulation, and standardization of herbal drugs with their validation to ensure quality, safety, and efficacy. He has made innovative, outstanding, and original contributions both in education and research in the area of natural products. Dr. Mukherjee is a Fellow of the Royal Society of Chemistry (FRSC), UK. He completed his masters and PhD in pharmacy from Jadavpur University and post-doctoral research from Leiden/Amsterdam Center for Drug Research, The Netherlands. His research career has been outstanding, including globally-acclaimed contributions on evaluation of the holistic medicine as useful bio-prospecting tools for the traditional medicine based drug discovery program so as to make them available from “Farm to Pharma . His work has led to many important national and international projects in the field of Natural Health Products. He has worked on leveraging innovations in traditional Indian medicine, particularly on rationally designed, carefully standardized, synergistic traditional herbal formulations and botanical drugs for their scientific validation on evidence based approaches. His efforts on development of integrated approaches for drug development from Indian traditional medicine have worldwide impact for the promotion of traditional medicine inspired drug discovery. Based on these works, he has to his credit more than 174 publications in peer reviewed impact journals, several patents and 20 books/book chapters on various aspects of herbal medicine. His research publications have a cumulative Impact Factor of 186.43. Google Citations database indicates that his works have h-Index- 41, i10-index- 126; which has been cited over 7630 times. He has worked as visiting scientist in several renowned universities abroad including The School of Pharmacy, University of London; King’s College London; Leiden/Amsterdam Center for Drug Research, Netherlands; School of Health Science, Tokushima University, Japan; Medical Research Council, Cape Town, South Africa. He has developed several products, and processes with partnership between industry and institutes. He has been awarded with many laurels from the Government of India and abroad; to name a few: the prestigious Commonwealth Academic Staff Fellowship from the Association of Commonwealth Universities (ACU), UK; Outstanding Service Award from the Drug Information Association (DIA), USA; Career Award for Young Teachers from the All India Council for Technical Education (AICTE), Government of India; Overseas Award from the Department of Biotechnology (DBT), BOYSCAST Fellowship from Department of Science & Technology (DST), Government of India; Young Pharmacy Teacher Award from the Association of Pharmaceutical Teachers of India; and the IPA Fellowship Award from the Indian Pharmaceutical Association (IPA). Dr. Mukherjee is working on the dissemination of knowledge on promotion and development of natural products with international coordination and collaboration on globalizing local knowledge and localizing global technologies in the area of traditional medicine. He has delivered over 200 lectures at different international and national podiums on leveraging innovations in traditional Indian medicine particularly on its validation for the safety, quality, and efficacy with the evidence based scientific claims. He has organized 16 potential national and international conferences, workshops, and seminars with the involvement of scientists all over the world. He is actively involved with several professional organizations. He is Member of the board on International Society for Ethnopharmacology, UK; Secretary of the Society for Ethnopharmacology (SFE), India; Council member of the Society for TCM Pharmaceutical Analysis, China; and others. Dr. Mukherjee is serving as Associate Editor of the Journal of Ethnopharmacology, Elsevier Science. He is the member of the editorial board of ten other Indian and international journals. He is also associated as advisor to different organizations and administrative bodies of the Government of India and abroad.
The development of new drugs is very complex, costly and risky. Its success is highly dependent on an intense collaboration and interaction between many departments within the drug development organization, external investigators and service providers, in constant dialogue with regulatory authorities, payers, academic experts, clinicians and patient organizations. Within the different phases of the drug life cycle, drug development is by far the most crucial part for the initial and continued success of a drug on the market.
This book offers an introduction to the field of drug development with a clear overview of the different processes that lead to a successful new medicine and of the regulatory pathways that are used to launch a new drug that are both safe and efficacious.
“This is the most comprehensive and detailed book on drug development I have ever read and I feel that it is likely to become a staple of drug development courses, such as those taught at Masters Level in my own University…. I think in the light of increasing integration of company and academic approaches to drug development both sides can read this book.. (and, therefore)… this book could not be more timely. “
Professor Mike Coleman, University of Aston., UK ( from his review of the final manuscript)
Authored by members of the British Bobath Tutors Association, Bobath Concept: Theory and Clinical Practice in Neurological Rehabilitation is a practical illustrated guide that offers a detailed exploration of the theoretical underpinning and clinical interventions of the Bobath Concept. This book guides the reader through general principles to more specific application of neurophysiological principles and movement re-education in the recovery of important areas, including moving between sitting and standing, locomotion and recovery of upper limb function.
About the Author
Sue Raine is Clinical Lead Physiotherapist at Walkergate Park for Neurorehabilitation and Neuropsychiatry, in Newcastle-upon-Tyne, and an experienced Bobath Tutor. Linzi Meadows is Clinical Director of the Manchester Neurotherapy Centre and Neurological Teaching Centre, as well as an Advanced Bobath Tutor. Mary Lynch-Ellerington F.C.S.P is Fellow of the Chartered Society of Physiotherapy and a Senior Bobath Instructor.
New and emerging directions in pharmaceutical research to better treat schizophrenia
Although the dopamine hypothesis has been the cornerstone of schizophrenia therapeutics, it is clear that dopamine-based approaches do not treat all aspects of the disease. Moreover, many schizophrenia patients fail to respond to current antipsychotics. Integrating chemistry, biology, and pharmacology, this book explores emerging directions in pharmaceutical research for drug targeting and discovery in order to find more effective treatments for schizophrenia, one of the most serious and widespread psychiatric diseases.
Targets and Emerging Therapies for Schizophrenia presents the basics of schizophrenia, drug targets for the disease, and potential new drugs and therapeutics. It begins with a discussion of prevalence and etiology. Then, it describes therapies such as dopamine agonists and phosphodiesterase (PDE) inhibitors as well as growing research aimed at addressing untreated symptoms. Next, the authors discuss receptor modulators, inhibitors, and targeting strategies for drug discovery. Both the neurobiological and chemical aspects of all major pharmacological targets are examined.
With contributions from an international team of pioneering pharmaceutical researchers, this book compiles the current knowledge in the field, setting the stage for new breakthroughs in the treatment of schizophrenia. Targets and Emerging Therapies for Schizophrenia:
- Provides a comprehensive resource for neuro-drug discovery and the development of molecular targets for schizophrenia treatment
- Draws from chemistry, biology, and pharmacology for more effective drug targeting and discovery
- Explores a wide range of receptors and molecular targets, including dopamine, PDEs, and neuropeptides
With Targets and Emerging Therapies for Schizophrenia as their guide, drug discovery and development scientists have the information they need to advance their own research so that new, more effective treatments for schizophrenia will soon be a reality.