Tapping Molecular Wilderness: Drugs from Chemistry, Biology, Biodiversity Interface
This book is for readers with some background in science, concerning the search for drugs, starting from molecular diversity in nature or molecular wilderness. Drug molecules may be used as such, or as starting points for improved drugs obtained from the interface of chemistry and biology. In some cases, the essential molecular features for drug properties from natural molecules may be identified and modified to more effective ones. In other cases, nature provides the targets, such as essential enzymes from infectious microorganisms, from which synthetic drugs can be designed. The mechanisms of action of drugs can be discerned by studying target-drug interactions. Nature may fight back, as in cases when microorganisms become resistant to drugs, but we can again use the chemistry-biology interface to obtain drugs which overcome the resistance. The battle goes on, hopefully with victory for both humans and balance of nature. This book differs from those available on the subject of natural products and drugs derived therefrom in that it looks at the broad picture on how materials and organisms from nature affect our health and how we have combined our knowledge in chemistry, biology, and biodiversity to promote our wellness from resources in the “molecular wilderness,” with caveats on sustainable utilization of these resources. It is therefore suitable, not only for readers interested in science and medicine, but also for those with interest in policy issues concerning sustainable development, environment, and issues concerning interaction of science and society in general.
About the Author
Prof. Yongyuth Yuthavong is senior research fellow at the National Science and Technology Development Agency (NSTDA) of Thailand. While working at Mahidol University, Thailand, he was given the “Outstanding Scientist of Thailand” Award (1984) for his research on malaria biochemistry. In 2004, he received the Nikkei Asia Prize for Science, Technology and Innovation from Nihon Keizai Shimbun, Inc., Japan, for his work on antimalarial drug targets. He is a former Minister of Science and Technology of Thailand (2006-2008) and was the first president of NSTDA (1992-1998). He is now involved in the development of drugs against drug-resistant malaria as well as policy issues for science and technology, and education in general. He has special interest in introducing science and technology to young people.
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Considered an essential resource by many in the field, Diving and Subaquatic Medicine remains the leading text on diving medicine, written to fulfil the requirements of any general physician wishing to advise their patients appropriately when a diving trip is planned, for those accompanying diving expeditions or when a doctor is required to assess and treat anyone who has been involved in a diving accident. For this fifth edition the original author, Carl Edmonds, is joined by a new team of collaborators and the content has been entirely refreshed and updated throughout. Clinical cases, a feature popular with readers, are expanded, as is the illustrative content. Established and emerging diseases of diving medicine are all covered in full, as is the latest in types of diving, including free and indigenous diving, and associated equipment. Each medical disorder is discussed from a historical, etiological, clinical, pathological, preventative and therapeutic perspective in the informative and accessible style that has made previous editions so popular.
About the Author
Carl Edmonds, formerly OIC of the Royal Australian Navy Diving Medical Unit, Foundation President of the South Pacific Underwater Medical Society and Director of the Australian Diving Medical Centre, Sydney, Australia Michael Bennett, conjoint associate professor in anaesthesia and diving and hyperbaric medicine, University of New South Wales, Sydney, Australia John Lippmann, founder, chairman and director of research, DAN (Divers Alert Network) Asia-Pacific, Ashburton, Australia Simon J. Mitchell, head, Department of Anaesthesiology, University of Auckland, New Zealand; and consultant in diving and hyperbaric medicine, Slark Hyperbaric Unit, North Shore Hospital, Auckland, New Zealand.
CPHIMS Review Guide: Preparing for Success in Healthcare Information and Management Systems 3rd Edition
Whether you’re taking the CPHIMS exam, or simply want the most current and comprehensive overview in healthcare information and management systems today – this completely revised and updated third edition has it all. But for those preparing for the CPHIMS exam, this book is an ideal study partner. The content reflects the exam content outline covering healthcare and technology environments; systems analysis, design, selection, implementation, support, maintenance, testing, evaluation, privacy and security; and administration leadership management. Candidates can challenge themselves with the sample multiple choice questions at the end of the book.
About the Author
HIMSS is a global voice, advisor and thought leader of health transformation through Health IT with a unique breadth and depth of expertise and capabilities to improve the quality, safety, and efficiency of health, healthcare and care outcomes. As the leading source of Health IT, HIMSS designs and leverages key data assets, predictive models and tools to advise global leaders, stakeholders and influencers of best practices in Health IT so they have the right information at the point of decision. Through its HIT network of over 1 million experts, over 200 knowledge exchanges and collaborations, including 60,000 plus members, HIMSS drives innovative; forward thinking around best uses of technology in support of better connected care, improved population health and low cost of care. HIMSS is a not for profit, headquartered in Chicago, Illinois with additional offices in North America, Latin America, Europe, United Kingdom and Asia.
UNDERSTANDING NORMAL AND CLINICAL NUTRITION, Ninth Edition, provides the most current and comprehensive coverage of the fundamentals of nutrition and nutrition therapy for an introductory course. The early chapters focus on “normal” nutrition, including digestion and metabolism, vitamins and minerals, and life cycle nutrition. The later chapters cover “clinical” nutrition–the pathophysiology and nutrition therapy for a wide range of medical conditions. The text integrates practical information and valuable resources to help students apply nutrition knowledge and skills to their daily lives and the clinical setting. Features, such as case studies, “How To” boxes with real-world examples, and study cards, help students apply the material and build their conceptual understanding. Regardless of the students’ background, the consistent level, approachable narrative, and careful explanations in UNDERSTANDING NORMAL AND CLINICAL NUTRITION will engage students and enable them to be actively involved in the field of nutrition.
About the Author
Ellie Whitney, Ph.D. grew up in New York City and received her BA and PhD degrees in English and Biology at Harvard and Washington Universities. She taught at both Florida State University and Florida A&M University, wrote newspaper columns on environmental matters for the TALLAHASSEE DEMOCRAT, and coauthored almost a dozen college textbooks on nutrition, health, and related topics, many of which repeatedly reappear as new editions. She spen three decades exploring outdoor Florida and studying its ecology, and then cowrote PRICELESS FLORIDA: NATURAL ECOSYSTEMS AND NATIVE SPECIES (Pineapple Press, 2004). Now retired, and more concerned about climate change than any other issue, she volunteers full-time for the nonpartisan national nonprofit Citizens Climate Lobby. Kathryn Pinna received her M.S. and Ph.D. in nutrition from the University of California at Berkeley. She has taught nutrition, food science, and human biology courses in the San Francisco Bay Area for over 25 years and has also worked as an outpatient dietitian, Internet consultant, and freelance writer. Her other publications include the textbooks Understanding Normal and Clinical Nutrition and Nutrition for Health and Health Care. She is a registered dietitian and member of the American Society for Nutrition and the Academy of Nutrition and Dietetics. Sharon Rady Rolfes is a registered dietician nutritionist and a founding member of Nutrition and Health Associates, an information resource center that maintains a research database on more than 1,000 nutrition-related topics. She has taught at Florida State University and coauthored several other college textbooks, including UNDERSTANDING NORMAL AND CLINICAL NUTRITION, 10th EDITION. In addition to writing, she serves as a consultant for various educational projects, and volunteers on the board of Working Well, a community initiative dedicated to creating a healthy workforce. A member of the Academy of Nutrition and Dietetics, Ms. Rady Rolfes received her MS in nutrition and food science from Florida State University.
About the Author
Robert N. Taylor, MD, PhD is Vice Chair for Research in the Department of Obstetrics and Gynecology at Wake Forest School of Medicine. Previously, he was Professor of Obstetrics and Gynecology at Emory University and Director of the Center for Reproductive Sciences at the University of California, San Francisco (UCSF). Dr. Taylor received his undergraduate education at Stanford University and completed the combined MD-PhD program at Baylor College of Medicine. His graduate work on the molecular biology of estrogen action was performed under the supervision of Roy G. Smith, PhD and Bert W. O’Malley, MD. Dr. Taylor trained as a resident in Obstetrics and Gynecology and subsequently as a fellow in Reproductive at UCSF. He then completed a postdoctoral fellowship with Lewis T. (“Rusty ) Williams, MD, PhD in the Howard Hughes Medical Institute at UCSF, where he studied the regulation of placental angiogenesis by growth factors and their receptors. He is a board-certified obstetrician-gynecologist and reproductive endocrinologist widely published in the areas of preeclampsia, embryonic implantation and endometriosis. Dr. Taylor serves on influential international, national and state executive committees including the American Board of Obstetrics and Gynecology, NIH Reproductive Scientist Development Program, several NIH Women’s Reproductive Health Research advisory boards, and the California Institute for Regenerative Medicine. He is a Past President of the Society for Gynecologic Investigation and honorary secretary of the World Endometriosis Society. Dr. James M. Roberts, MD is Professor of Obstetrics and Gynecology and Epidemiology and Clinical and Translational Research at the University of Pittsburgh. His research includes fundamental, clinical and health services approaches to the understanding and management of adverse pregnancy outcomes. He led an NIH RCT (10,000 women) of antioxidant vitamins to prevent preeclampsia. He has been the recipient of lifetime achievement awards by the International Society for the Study of Hypertension in Pregnancy, the SGI and the Preeclampsia Foundation Hope. He has served or serves on the editorial boards of journals including, Placenta, Journal of Clinical Endocrinology, Metabolism. Reproductive Sciences, Women’s Health Issues and Hypertension. He has been on scientific review boards of the NIH, the CIHR, the FDA and the March of Dimes. He was the chair of the NICHD Maternal Fetal Medicine Network from 1990 -1999 and is past president of the Perinatal Research Society, the North American Society for the Study of Hypertension in Pregnancy, the Society of Gynecological Investigation, and the International Society for the Study of Hypertension in Pregnancy. He was formally admitted to fellowship ad eundem of the Royal College of Obstetricians and Gynaecologists in September 2000. He has been elected to membership in the Institute of Medicine of the National Academy of Sciences. He has also received mentoring awards from the NICHD and the Society of Gynecological Investigation. F. Gary Cunningham, MD is holder of the Miguel and Beatrice Distinguished Chair of Obstetrics and Gynecology at the University of Texas Southwestern Medical Center. He is also chair emeritus of the Department of Obstetrics and Gynecology, having served in that position for 22 years. Dr. Cunningham received his MD degree from the Louisiana State University School of Medicine and completed a residency in Obstetrics and Gynecology at Charity Hospital of New Orleans. Following this, he completed a fellowship in Maternal-Fetal Medicine at UT Southwestern and Parkland Hospital in Dallas, Texas. His early career was influenced by Dr. Jack Pritchard, and together they performed extensive clinical and laboratory research in preeclampsia and eclampsia, coagulopathies and other hematological complications of pregnancy, as well as a myriad of medical and surgical disorders complicating pregnancy. He has served as an examiner for the American Board of Obstetrics and Gynecology, served as tor for an NIH consensus conference, and is a member of the Society for Maternal-Fetal Medicine, Society for Gynecologic Investigation, and the American Gynecological and Obstetrical Society. Dr. Cunningham has served as senior editor of the 18th through 24th editions of Williams Obstetrics. Dr. Marshall Lindheimer, a professor (emeritus) of Medicine, Obstetrics & Gynecology, and Clinical Pharmacology at the University of Chicago is a longtime admirer and was a longtime friend of the late Leon Chesley. Chief Editor of the second and third editions of this text and leader of the search for its current chief editor, Dr. Lindheimer prefers to be called “editor emeritus despite continuing to comment and publish in the area of the hypertension and renal disease in pregnancy. His CV contains over 400 publications including a monograph, other edited texts, reviews, text chapters and articles devoted to both basic and clinical research. Boarded in Internal Medicine and Nephrology, he is the recipient of many awards and honors that include an honorary membership in the Society of Maternal Fetal Medicine and an ad eundem of the Royal College of Obstetrics and Gynecology London. He has received an Honoris Causa degree from Bern University, the Chesley award from the International Society for the Study of Hypertension in Pregnancy, the Belding Scribner Award from the American Society of Nephrology and the Joseph Bolivar DeLee Humanitarian award from the Board of Directors at Lying-in Hospital, Chicago. Both the National Kidney Foundation of Illinois and the Preeclampsia Foundation have honored him as well. Of note on his wall is a congratulatory letter from President Obama, recognizing his accomplishments in regard to the health of pregnant women and their unborn children.