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Edited by three of the world’s leading pharmaceutical scientists, this is the first book on this important and hot topic, containing much previously unpublished information. As such, it covers all aspects of green chemistry in the pharmaceutical industry, from simple molecules to complex proteins, and from drug discovery to the fate of pharmaceuticals in the environment. Furthermore, this ready reference contains several convincing case studies from industry, such as Taxol, Pregabalin and Crestor, illustrating how this multidisciplinary approach has yielded efficient and environmentally-friendly processes. Finally, a section on technology and tools highlights the advantages of green chemistry.
About the Author
Peter Dunn received his PhD from Imperial College London in 1987 working under the supervision of Professor Charles Rees. Postdoctoral work followed with Prof. Albert Eschenmoser at the ETH, Zurich and with Prof. Henry Rapaport at the University of California, Berkeley. In 1989 he joined Pfizer and was involved with the invention of the commercial processes to make several medicines including “Viagra”, Emselex, Revation and Sampatrilat. In 2000 he became Director of Chemical R & D at Pfizer and was responsible for the filing and transfer to manufacturing of human and animal medicines such as Voriconazole, Darifenacin, Fosfluconazole and Dirlotapide. In 2006 he took up his current role as Global Green Chemistry lead for Pfizer. He is currently co-chair of the Green Chemistry Institute Pharmaceutical Roundtable and a member of the editorial board for the journal of Green Chemistry. Andrew Wells obtained his PhD in organophosphorous and organometallic chemistry from Essex University, before joining the Chemical Development Group of SmithKline & French in 1986, which later became SmithKline Beecham. In 1999 he received a SKB corporate award for green chemistry/technology. In 2000, he joined AstraZeneca in Global Process R & D where he is currently a Senior Principal Scientist and heads the AZ GPRD Green Chemistry group. He is an active member of the ACS Green Chemistry Institute Pharmaceutical Roundtable and has acted as an advisor to the UK Chemical Innovation Knowledge Transfer Network and the UK Technology Strategy Board. A keen supporter of the industry-academia interface, having been involved closely with several major collaborations such as the Centre for Biocatalysis at Manchester and the Institute of Process R & D at Leeds University, he has also been an industrial supervisor to around 20 PhD and MSc students. Michael Williams obtained his chemistry BSc from King’s College, London, and spent time as a medicinal chemist at ICI Pharmaceuticals (Alderley Park), before obtaining his PhD working with Professor Charles Rees at the University of Liverpool. He joined the Chemical R & D department at Pfizer at Sandwich in 1972, where his career responsibilities included the Medicinal Chemistry/Development interface, and technology adoption. In addition to his experience with approximately 50 early drug candidates, he played a significant role in the late development, filing and commercializing of many agents including Zoloft, Viagra and Relpax. He became Executive Director and Departmental Head of UK Chemical R & D in 2003, leading a significant growth to 117 laboratory staff, and helping to build a 40 strong Material Sciences group. Since retiring from Pfizer in 2007, he has been an independent consultant, in addition to his work in editing and scientific writing.
This second volume on a burgeoning field retains the proven concept of the spectacularly successful first one, extending and supplementing it. Individual sections are each dedicated to nanoparticles, nanostructures and patterns, nanodevices and machines, and nanoanalytics. Essential reading for an entire generation of scientists, this authoritative survey defines one of the most important new scientific fields to have emerged for many decades.
There are various books on green chemistry on the market, but without focus on sustainable industrial processes. This resource provides an overview of the new trends and hot topics in process design, describing the challenge of designing industrial chemical processes that are up-to-date, sustainable, and economically feasible. The industrial applications are presented directly by the companies – a veritable ‘Who’s Who’ of the chemical industry – that developed these innovative technologies. It provides an essential reference for chemical engineers, chemists in industry, process engineers, catalytic chemists, materials scientists, and environmental chemists.
About the Author
Professor Fabrizio Cavani received his PhD in Industrial Chemistry from the University of Bologna in 1986. From 1986 to 1990 he worked at the Catalysis Centre of EniChem, where he investigated new catalysts for the oxychlorination of ethylene and for the Alkylation of benzene with propene, and gave technical assistance to the catalysts production division. In 1990 he joined the Catalytic Processes Development team at the University of Bologna becoming Associate Professor of Industrial Chemistry there in 2000. Hee is author of over 200 journal articles, 25 patents, two books on catalytic selective oxidation and one book on the development and management of chemical processes and is the editor of 4 special journal issues. he is on the board of the Italian Platform for Sustainable Chemistry. Professor Gabriele Centi is Full Professor of Industrial Chemistry at the University of Messina and a past President of the European Federation of Catalysis Societies. He is the Coordinator of the Network of Excellence IDECAT and Co-Director of the European Laboratory for Catalysis and Surface Science and President of ERIC (European Research Institute of Catalysis). His research activities lie in the development of industrial heterogeneous catalysts for the field of sustainable chemical processes, environmental protection and clean energy. He is author of over 260 journal articles, editor and/or author of 7 books, editor of 7 special issues, chairman of several International Congresses and Editor of the Wiley-VCH journal ChemSusChem. He is also a Core Team member for the European Technology Platform for Sustainable Chemistry. Professor Siglinda Perathoner is Associate Professor of Industrial Chemistry at the University of Messina. After some years experience in the field of photophysics and photochemistry of supramolecular systems, she moved to the area of catalysts. In 2001 she joined the University of Messina where her most recent research interest include nanostructured zeolites, catalytic membranes, catalysts for reactions in supercritical fluids, catalysts for waste water purification and remediation, photo(electro)catalytic conversion of carbon dioxide, and fuel cells. Her aim is the design of novel catalytic materials for sustainable processes, environment protection, and cleaner energy. She is author of over 130 publications, including 15 reviews, has been co-editor of a book and two special journal issues, and has contributed to various entries in encyclopedias. Professor Ferruccio Trifiro is Full Professor of Industrial Chemistry at the University of Bologna. Currently he is the Dean of the Faculty of Industrial Chemistry, and Director of the journal “La Chimica e L’Industria” (Chemistry and Industry). His main research activities lie in the development of heterogeneous catalysts for processes in the field of petrochemistry, environmental protection, fine chemicals and specialties production, clean energy and hydrogen production. He is a past Chairman of the World Congress of Selective Oxidation. He is author of over 300 papers in International Journals, two books on Selective Oxidation, and of 18 patents.